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+"87345","hsa_circ_0003755","hsa-miR-671-5p" +"87346","hsa_circ_0003755","hsa-miR-7" +"87347","hsa_circ_0003755","hsa-miR-767-3p" +"87348","hsa_circ_0003755","hsa-miR-767-5p" +"87349","hsa_circ_0003755","hsa-miR-769-5p" +"87350","hsa_circ_0003755","hsa-miR-873-5p" +"87351","hsa_circ_0003755","hsa-miR-876-3p" +"87352","hsa_circ_0003755","hsa-miR-888-5p" +"87353","hsa_circ_0003755","hsa-miR-892b" +"87354","hsa_circ_0003755","hsa-miR-935" +"87355","hsa_circ_0003755","hsa-miR-942-5p" +"87356","hsa_circ_0003755","hsa-miR-944" +"87357","hsa_circ_0003755","hsa-miR-99a-5p" +"87358","hsa_circ_0003755","hsa-miR-99b-5p" +"87359","hsa_circ_0017713","hsa-miR-1206" +"87360","hsa_circ_0017713","hsa-miR-1225-5p" +"87361","hsa_circ_0017713","hsa-miR-1257" +"87362","hsa_circ_0017713","hsa-miR-1279" +"87363","hsa_circ_0017713","hsa-miR-1324" +"87364","hsa_circ_0017713","hsa-miR-153-3p" +"87365","hsa_circ_0017713","hsa-miR-1825" +"87366","hsa_circ_0017713","hsa-miR-431-5p" +"87367","hsa_circ_0017713","hsa-miR-515-5p" +"87368","hsa_circ_0017713","hsa-miR-526b-5p" +"87369","hsa_circ_0017713","hsa-miR-548c-3p" +"87370","hsa_circ_0017713","hsa-miR-548p" +"87371","hsa_circ_0017713","hsa-miR-549a-3p" +"87372","hsa_circ_0017713","hsa-miR-555" +"87373","hsa_circ_0017713","hsa-miR-556-5p" +"87374","hsa_circ_0017713","hsa-miR-578" +"87375","hsa_circ_0017713","hsa-miR-580-3p" +"87376","hsa_circ_0017713","hsa-miR-599" +"87377","hsa_circ_0017713","hsa-miR-605-5p" +"87378","hsa_circ_0017713","hsa-miR-607" +"87379","hsa_circ_0017713","hsa-miR-615-3p" +"87380","hsa_circ_0017713","hsa-miR-646" +"87381","hsa_circ_0017713","hsa-miR-654-3p" +"87382","hsa_circ_0017713","hsa-miR-766-3p" +"87383","hsa_circ_0017713","hsa-miR-875-5p" +"87384","hsa_circ_0007694","hsa-miR-1252-5p" +"87385","hsa_circ_0007694","hsa-miR-1282" +"87386","hsa_circ_0007694","hsa-miR-136-5p" +"87387","hsa_circ_0007694","hsa-miR-490-5p" +"87388","hsa_circ_0007694","hsa-miR-515-5p" +"87389","hsa_circ_0007694","hsa-miR-587" +"87390","hsa_circ_0007694","hsa-miR-766-3p" +"87391","hsa_circ_0007694","hsa-miR-885-5p" diff --git a/source/data_circGPA_preprocess.R b/source/data_circGPA_preprocess.R index bead9a3043d2014a0384d09dc1954f0075e4cdbb..50a2d71019d1e69955363ef8270f335142d3f09d 100644 --- a/source/data_circGPA_preprocess.R +++ b/source/data_circGPA_preprocess.R @@ -11,7 +11,7 @@ f_prior_circ_mirna <- "data/circrna-mirna-interactions.csv" f_prior_mi_mrna <- "data/mirna-mrna-interactions.csv" ### Set global variables with online database access -httr::set_config(config(ssl_verifypeer = FALSE)) +httr::set_config(httr::config(ssl_verifypeer = FALSE)) if(!exists("DB_mart")) { DB_mart <<- useMart(biomart="ensembl", dataset="hsapiens_gene_ensembl") @@ -112,7 +112,7 @@ circGPA_mirnas <- function() ret <- readRDS(f_cached_mirna_names) return(ret) } - miRNATab=getMiRNATable(version="v22",species="hsa") + miRNATab=miRBaseConverter::getMiRNATable(version="v22",species="hsa") # TODO -> convert miRNA to suffix-removed version diff --git a/source/skeleton.R b/source/skeleton.R index 31357ab4d9e2106b2c75af5393443c9efacdabcb..46423d08b57a27ad05a036f88d125e696540d68c 100644 --- a/source/skeleton.R +++ b/source/skeleton.R @@ -9,35 +9,38 @@ src.cppsource("skeleton.cpp") BGe_compute <- function(adj, param) { - nodes_cand <- 1:nrow(adj) + nodes_cand <- colnames(adj) sc <- sum(sapply(nodes_cand, function(node) { - neights <- which(adj[node,] > 0) + neights <- names(which(adj[,node] > 0)) score <- BGe_node_compute(node, neights, param) return(score) }) ) + return(sc) } -BGe_change <- function(from, to, action_is_add, sizes, score_prev, G_adjs, param) +BGe_change <- function(part_id, from, to, action_is_add, score_prev, G_adjs, param) { - part_id <- sum(from > sizes) + 1 - adj <- G_adjs[[part_id]] - prev <- adj[from, to] - + + node <- colnames(adj)[to] + neights <- names(which(adj[,node] > 0)) score_node_prev <- BGe_node_compute(node, neights, param) adj[from, to] <- action_is_add node <- colnames(adj)[to] - neights <- names(which(adj[node,] > 0)) - + neights <- names(which(adj[,node] > 0)) score_node <- BGe_node_compute(node, neights, param) - adj[from, to] <- prev - return(score_node - score_node_prev + score_prev) + adj[from, to] <- (1 - action_is_add) + + diff <- score_node - score_node_prev + ret <- list(score=diff + score_prev, diff=diff) + + return(ret) } @@ -57,7 +60,7 @@ BGe_change <- function(from, to, action_is_add, sizes, score_prev, G_adjs, param #' https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957076/ #' #' @param G_adjs A list of adjacency matrices across each partition interaction, for example: list(CIRC->MI, MI->M) -#' @param B_PKs A list of prior matrices for each partition interaction, for example: list(CIRC->MI, MI->M) +#' @param B_PKs A list of prior matrices for each partition interaction, for example: list(CIRC->MI, MI->M), ! modified to scores [1,0.5,0] #' @param N A total number of genes #' @returns E(G), the prior energy function for a given graph #' @@ -72,16 +75,29 @@ Energy_compute <- function(G_adjs, B_PKs, N) for(i in 1:length(G_adjs)) # for each partition interaction separately { + # IntOMICS scoring # if 1 ---> 1-B(i,j), ...., if 0 ----> B(i,j) - E <- sum(G_adjs[[i]] * (1-B_PKs[[i]]) + (1-G_adjs[[i]]) * B_PKs[[i]]) + # E <- sum(G_adjs[[i]] * (1-B_PKs[[i]]) + (1-G_adjs[[i]]) * B_PKs[[i]]) + + + # BP(Isci) scoring + # if 1 ---> 1-B(i,j), ...., if 0 ----> 1 + E <- sum(1 - B_PKs[[i]] * G_adjs[[i]]) + + # Add non-blocked E_non_blocked <- E_non_blocked + ncol(B_PKs[[i]]) * nrow(B_PKs[[i]]) } + + # in both scoring we add +1 for each blocked edge too + # to compute it we just compute non-blocked and then: + # [TOTAL] - [non-BLOCKED] = [BLOCKED] = N^2 - [non-BLOCKED] E <- (E + N*N - E_non_blocked) + return(E) } #' -#' Compute a score-P(G) for a given graph. This part of function should be called +#' Compute a score~proportional to~ log P(G) for a given graph. This part of function should be called #' #' For an integral formula of the Bayesian prior see: #' https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957076/ @@ -103,25 +119,31 @@ pP_G_compute <- function(E, N, beta_L, beta_H) ret <- exp(-U * beta_L) - exp(-U * beta_H) ret <- ret / delta_beta ret <- ret / U + ret <- log(ret) return(ret) } -P_G_change <- function(from, to, action_is_add, sizes, energy_prev, B_PKs, beta_L, beta_H) +P_G_change <- function(part_id, from, to, action_is_add, N, energy_prev, B_PKs, beta_L, beta_H) { - part_id <- sum(from > sizes) + 1 - B_PK_mat <- B_PKs[[part_id]] - b_i_j <- B_PK_mat[from, to] + + # IntOMICS change: + # if edge included ----> (1 - b_i_j) + # if edge no included -> (b_i_j) + # difference: + # remove ---------> +(1 - 2 * b_i_j) + # add ---------> -(1 - 2 * b_i_j) u_change <- 1 - 2 * b_i_j + u_change <- (1 - 2 * action_is_add) * u_change - if(action_is_add) - { - u_change <- -1 * u_change - } - N <- sum(sizes) + + # Isci change + # remove -> + b_i_j + # add -> - b_i_j + u_change <- (1 - 2 * action_is_add) * b_i_j U.new <- energy_prev + u_change score <- pP_G_compute(U.new, N, beta_L, beta_H) @@ -170,23 +192,32 @@ P_G <- function(G_adjs, B_PKs, beta_L, beta_H) #' P_D_G <- function(G_adjs, param_in) { - pDG <- 0 + pDG1 <- 0 for(i in 1:length(G_adjs)) # for each partition interaction separately { adj <- G_adjs[[i]] - cat(paste(i, "/", length(G_adjs), "\n")) - pDG <- pDG + BGe_compute(adj, param_in) + #cat(paste(i, "/", length(G_adjs), "\n")) + pDG1 <- pDG1 + BGe_compute(adj, param_in) } - return(pDG) + + nodes_cand <- rownames(G_adjs[[1]]) + pDG2 <- sum(sapply(nodes_cand, function(node) + { + score <- BGe_node_compute(node, integer(0), param_in) + return(score) + }) + ) + + return(pDG1 + pDG2) } #' -#' Compute a score proportional to P(G | D) for a given graph, e.g., -#' P(G | D) = P(D|G) P(G) ~ (BGe score, data only) * (Prior knowledge) -#' +#' Compute a score list: [log P(D|G), log P(G)] for a given graph, e.g., +#' log P(G | D) = log P(D|G) + log P(G) +#' ~ log (BGe score, data only) + log (Prior knowledge) #' #' The proportionality is the absence of normalization constant, e.g., -#' each score is the P(G|D) multiplied by some constant +#' prior score is the P(G|D) multiplied by some constant #' #' @param G_adjs A list of adjacency matrices across each partition interaction, for example: list(CIRC->MI, MI->M) #' @param B_PKs A list of prior matrices for each partition interaction, for example: list(CIRC->MI, MI->M) @@ -200,24 +231,48 @@ score_G <- function(G_adjs, B_PKs, beta_L, beta_H, param_in) pG_list <- P_G(G_adjs, B_PKs, beta_L, beta_H) pDG <- P_D_G(G_adjs, param_in) #pGD <- pG * pDG - return(c("pG"=pG_list$score, "pDG"=pDG, "energy"=pG_list$energy)) + return(c("pG"=pG_list$score, "pDG"=pDG, "energy"=pG_list$energy, "pG_change"=0, "pDG_change"=0)) } - +#' +#' Compute a change score list: [log P(D|G), log P(G)] for a given graph, e.g., +#' [log P(D|G), log P(G)] after 1 action of ADD/DELETE +#' +#' +#' @param G_adjs A list of adjacency matrices across each partition interaction, for example: list(CIRC->MI, MI->M) +#' @param B_PKs A list of prior matrices for each partition interaction, for example: list(CIRC->MI, MI->M) +#' @param beta_L A lower threshold on prior's weight (numeric) +#' @param beta_H An upper threshold on prior's weight (numeric) +#' @param param_in A precomputed parameters for BGe computation +#' @param sizes A vector of each partition's size +#' @param score_prev A previous return of score_G/score_change_G +#' @param part_id An index of G_adjs partitions +#' @param from A row index to add to G_adjs partition +#' @param to A column index to add to G_adjs partition +#' @param action_is_add A boolean defining the action, if TRUE -> add edge, if FALSE -> delete edge +#' +#' +#' @returns P(D | G) = BGe score of a given graph after change +#' score_change_G <- function(G_adjs, B_PKs, beta_L, beta_H, param_in, sizes, - score_prev, from, to, action_is_add) + score_prev, part_id, from, to, action_is_add) { ret <- score_prev N <- sum(sizes) # ! Convert C++ indices to Rcpp indices(+1) ! - AC <- P_G_change(from+1, to+1, action_is_add, sizes, ret["energy"], B_PKs, beta_L, beta_H) - B <- BGe_change(from+1, to+1, action_is_add, sizes, ret["pDG"], G_adjs, param_in) - - ret["pG"] <- ret["pG"] + AC$score - ret["pDG"] <- ret["pDG"] + B - ret["energy"] <- ret["energy"] + AC$energy + AC <- P_G_change(part_id+1, from+1, to+1, action_is_add, N, ret["energy"], B_PKs, beta_L, beta_H) + B <- BGe_change(part_id+1, from+1, to+1, action_is_add, ret["pDG"], G_adjs, param_in) + + prev <- ret + + ret["pG"] <- AC$score + ret["pDG"] <- B$score + ret["energy"] <- AC$energy + ret["pG_change"] <- AC$score - prev["pG"] + ret["pDG_change"] <- B$diff + return(ret) } @@ -232,14 +287,14 @@ score_change_G <- function(G_adjs, B_PKs, beta_L, beta_H, param_in, #' @param PK A prior knowledge matrix, (N x N) #' @param SK A skeleton inferred from MMPC_tripartite, (N x N) #' @param parts A list of partitions, total unique elements: (N) -#' @param I A global number of iterations to perform, (integer) +#' @param I A global number of iterations to perform, default=1000 (integer) #' @param alpha A threshold prob.value for final edge cutoff (alpha) #' @param debug Logical, TRUE if a debugging print is needed (logical) #' @param beta_L A lower threshold on prior's weight, default = 0.5 (numeric) #' @param beta_H An upper threshold on prior's weight, default=10.5 (numeric) #' @returns A binary matrix, the final inferred Bayesian net (N x N) #' -SK_SS_tripartite <- function(GE, PK, SK, parts, I=1000, debug=FALSE, alpha=0.05, beta_L=0.5, beta_H=10.5) +SK_SS_tripartite <- function(GE, PK, SK, parts, I=1, debug=FALSE, alpha=0.05, beta_L=0.5, beta_H=10.5) { if(missing(GE) || missing(PK) || missing(SK) || missing(parts)) { stop("Some of the input arguments were not provided, need: Ge, PK, SK, parts") @@ -278,13 +333,23 @@ SK_SS_tripartite <- function(GE, PK, SK, parts, I=1000, debug=FALSE, alpha=0.05, stop("partitions should contain all genes, e.g., length(unlist(unique(parts))) == N") } + # Remove zero rows + zeroGenes <- names(which(colSums(GE) == 0)) + if(length(zeroGenes) > 0) + { + cat("Removing zero-count genes: ", zeroGenes, "\n") + + for(i in 1:length(parts)) + { + prev <- parts[[i]] + parts[[i]] <- prev[!(prev %in% zeroGenes)] + } + } + # Extract sizes of every partitions sizes <- unlist(lapply(parts, length)) + cat("Partition have sizes of: ", sizes, "\n") - # prepare BGe score parameters - myScore <- scoreparameters_BiDAG_BGe(n = ncol(GE), data = GE) - param_in <- list(n=myScore$n, awpN=myScore$awpN, TN=myScore$TN, scoreconstvec=myScore$scoreconstvec) - remove(myScore) # Extract every partition's GE,PK,SK parts GE_in <- list() @@ -311,6 +376,7 @@ SK_SS_tripartite <- function(GE, PK, SK, parts, I=1000, debug=FALSE, alpha=0.05, # convert PK to prior scores as in IntOMICS/Bayesian Network Prior(Isci) subPK <- subPK * 0.5 + 0.5 # ---> 1 = prior, 0.5 = no prior, but allowed edge + # all non-allowed edges are removed explicitly by list PK_in[[i-1]] <- subPK remove(subPK) @@ -321,17 +387,30 @@ SK_SS_tripartite <- function(GE, PK, SK, parts, I=1000, debug=FALSE, alpha=0.05, remove(subSK) } - #val <- P_D_G(SK_in, param_in) - - vals <- score_G(SK_in, PK_in, beta_L, beta_H, param_in) - vals_change <- score_change_G(SK_in, PK_in, beta_L, beta_H, param_in, sizes, vals, 0, 5, TRUE) - - - + # prepare BGe score parameters + # this is a large computation that computes a large parameter matrix: + # N x N, where N is the sum of sizes, e.g., total number of genes + cat("Computing large BGe matrix...\n") + if(FALSE) + { + myScore <- scoreparameters_BiDAG_BGe(n = ncol(GE), data = GE) + param_in <- list(n=myScore$n, awpN=myScore$awpN, TN=myScore$TN, scoreconstvec=myScore$scoreconstvec) + remove(myScore) + } + else{ + cat("Reading from a global var/file, TODO delete!") + #param_in <- readRDS("param_in.RData") + param_in <- GLOBAL_PARAM_IN + } - return(0.0) + cat("TN matrix have a size of: ", dim(param_in$TN), "\n") + + #vals <- score_G(SK_in, PK_in, beta_L, beta_H, param_in) + #vals_change <- score_change_G(SK_in, PK_in, beta_L, beta_H, param_in, sizes, vals, 0, 5, TRUE) + + set.seed(0) return(c_SK_SS(GE_in,PK_in,SK_in, sizes, param_in, I, debug, alpha, beta_L, beta_H, score_G, score_change_G)) -} \ No newline at end of file +} diff --git a/source/skeleton.cpp b/source/skeleton.cpp index 0e7159bf71adf21b0da26608cffd8cf0581f7175..ccd6883cf4cd1815cd2a61bb17c359a7517ee12b 100644 --- a/source/skeleton.cpp +++ b/source/skeleton.cpp @@ -5,13 +5,14 @@ #include <numeric> #include <bitset> #include <cstring> +#include <string> #include <vector> +#include <cmath> + // [[Rcpp::depends(RcppArmadillo)]] #include <RcppArmadillo.h> - #include <RcppArmadilloExtensions/sample.h> - //#include <Rcpp.h> using Rcpp::Rcout; @@ -30,116 +31,27 @@ using std::bitset; typedef unsigned int uint32_t; -enum ChangeType -{ - ADD = true, - DELETE = false -}; +/** + * This part will be the separate header file for tuple hash + Trie data structures + */ +#include <tuple> +typedef std::tuple<uint32_t, uint32_t, uint32_t> key_t; -struct Bitset2D { - uint8_t** array; - uint32_t n; - uint32_t m; - - - Bitset2D(uint32_t n, uint32_t m){ - Rcout << "Created a bitmap of size: " << n << "x" << m << "\n"; - this->n = n; - this->m = m; - - array = new uint8_t*[n]; - uint32_t sz = (m + 7) / 8; - - for(uint32_t i = 0; i < n; i++) - { - array[i] = new uint8_t[sz]; - std::memset(array[i], 0, sizeof *(array[i]) * sz); - } - } - - ~Bitset2D() - { - for(uint32_t i = 0; i < n; i++) - { - delete[] array[i]; - } - delete[] array; - } - - void set(uint32_t x, uint32_t y, bool v) - { - uint8_t val = array[x][y/8]; - uint32_t i = y % 8; - if(v){ - val |= 1 << i; - } - else{ - val &= ~(1 << i); - } - - array[x][y/8] = val; - } - - bool get(uint32_t x, uint32_t y) +struct key_hash : public std::unary_function<key_t, std::size_t> +{ + std::size_t operator()(const key_t& k) const { - uint8_t val = array[x][y/8]; - uint32_t i = y % 8; - return (val & (1<<i)) != 0; + return std::get<0>(k) ^ std::get<1>(k) ^ std::get<2>(k); } - - }; -// [[Rcpp::export]] -double tst() + +enum ChangeType { - uint32_t n = 9, m = 9; - Bitset2D t = Bitset2D(n, m); - - t.set(2,2, ADD); - t.set(1,5, ADD); - t.set(0,3, ADD); - - for(int i = 0; i < n; i++) - { - for(int j = 0; j < m; j++) - { - Rcout << t.get(i,j) << " "; - } - Rcout << "\n"; - } - Rcout << "\n"; - - - t.set(0, 3, DELETE); - for(int i = 0; i < n; i++) - { - for(int j = 0; j < m; j++) - { - Rcout << t.get(i,j) << " "; - } - Rcout << "\n"; - } - Rcout << "\n"; - - t.set(7, 2, ADD); - t.set(7, 2, DELETE); - t.set(7, 4, true); - t.set(7, 5, true); - - for(int i = 0; i < n; i++) - { - for(int j = 0; j < m; j++) - { - Rcout << t.get(i,j) << " "; - } - Rcout << "\n"; - } - Rcout << "\n"; - - return 0.0; -} + ADD = true, + DELETE = false +}; struct GraphChange @@ -147,23 +59,26 @@ struct GraphChange GraphChange* next = nullptr; GraphChange* prev = nullptr; + // unordered_map< + // tuple<uint32_t, uint32_t, uint32_t>, + // std::vector<GraphChange*>, + // std::hash_tuple::hash<tuple<uint32_t, uint32_t, uint32_t>> + // > next; + std::unordered_map< + const key_t, + GraphChange*, + key_hash + > + next_map; + + + ChangeType type; uint32_t from; uint32_t to; uint32_t listID; - - GraphChange* forward(Bitset2D* adj) - { - adj->set(from, to, type); - return next; - } - GraphChange* backward(Bitset2D* adj) - { - adj->set(from, to, !type); - return prev; - } - + bool is_graph; GraphChange* forward(List& adjs) { @@ -184,9 +99,27 @@ struct GraphChange return prev; } + + + + + + }; + + + +// [[Rcpp::export]] +double tst() +{ + + + return 0.0; +} + + struct IData { const List* GE; @@ -210,19 +143,14 @@ struct ISettings class Network { protected: - //static inline Function f_rnorm = Function("rnorm"); - //static inline Function f_unlist = Function("unlist"); - uint32_t N; // number nodes uint32_t M; // number samples - Bitset2D* ADJ = nullptr; // N x N boolean matrix, could be reduced - IData input_data; ISettings settings; - IntegerMatrix counts; - + NumericMatrix counts; + NumericMatrix current_counts; std::vector<GraphChange*> V_G; @@ -244,12 +172,6 @@ public: ~Network() { - if(ADJ != nullptr) - { - delete ADJ; - } - - if(V_G.size() == 0) { return; @@ -271,6 +193,9 @@ public: { Rcout << "partialSK-SS, Iteration: " << i << "\n"; this->partialSK_SS_phase1_iter(); + + + } } @@ -300,53 +225,89 @@ protected: ); - double score = (twoScores[0] * twoScores[1]); - const List* SK_list = this->input_data.SK; + //Rcout << twoScores << "\n"; + //Rcout << "Score of empty G0: " << twoScores[0] * twoScores[1] << "\n"; + const List* SK_list = this->input_data.SK; + // for loop over 1...N // for loop over neighbors // try add edge for(uint32_t i = 0; i < SK_list->length(); i++) { const IntegerMatrix& sk = (*SK_list)[i]; - - for(uint32_t j = 0; j < sk.ncol(); j++) + + Rcout << sk << "\n"; + + // Random permutation of the indices + uint32_t num = sk.ncol() * sk.nrow(); + IntegerVector xy = Rcpp::sample(num, num); + + + // It is necessary to do 2d loop in COL, ROW order, since + // rows are local in memory by Rcpp standard + for(uint32_t j = 0; j < (uint32_t)sk.ncol(); j++) { - for(uint32_t k = 0; k < sk.nrow(); j++) + //Rcout << "\rSituation: " << i << ", " << j << "\n"; + for(uint32_t k = 0; k < (uint32_t)sk.nrow(); k++) { - if(sk(j,k) == 0) - continue; + // extract 2D coords from 1D sample + uint32_t lin = xy[j * sk.nrow() + k] - 1; + uint32_t r = lin % sk.nrow(); + uint32_t c = lin / sk.nrow(); + + + if(sk(r,c) == 0) // <<< this chunk, but written without if + continue; - this->tryPerformMove(G, &score, i, j, k, ChangeType::ADD); + + this->tryPerformMove(G, &twoScores, i, r, c, ChangeType::ADD); + + //"\014" << + Rcout << + i << "," << j << "," << k << " /" << + (SK_list->length()) << "," << (uint32_t)sk.ncol() << "," << (uint32_t)sk.nrow() << + "\n"; } } } - + return; // for loop over 1...N // for loop over neighbors // try remove/add edge for(uint32_t i = 0; i < SK_list->length(); i++) { - const IntegerMatrix& g = G[i]; + const IntegerMatrix& gz = (*SK_list)[i]; + + // Random permutation of the indices + uint32_t num = gz.ncol() * gz.nrow(); + IntegerVector xy = Rcpp::sample(num, num); - for(uint32_t j = 0; j < g.ncol(); j++) + + // It is necessary to do 2d loop in COL, ROW order, since + // rows are local in memory by Rcpp standard + for(uint32_t j = 0; j < (uint32_t)gz.ncol(); j++) { - for(uint32_t k = 0; k < g.nrow(); j++) + //Rcout << "\rSituation: " << i << ", " << j << "\n"; + for(uint32_t k = 0; k < (uint32_t)gz.nrow(); k++) { - if(g(j,k) == 0) - { - this->tryPerformMove(G, &score, i, j, k, ChangeType::ADD); - } - else{ - this->tryPerformMove(G, &score, i, j, k, ChangeType::DELETE); - } + // extract 2D coords from 1D sample + uint32_t lin = xy[j * gz.nrow() + k] - 1; + uint32_t r = lin % gz.nrow(); + uint32_t c = lin / gz.nrow(); + + + if(gz(r,c) == 0) // <<< this chunk, but written without if + this->tryPerformMove(G, &twoScores, i, r, c, ChangeType::ADD); + else + this->tryPerformMove(G, &twoScores, i, r, c, ChangeType::DELETE); } } } - + delete &G; } @@ -359,15 +320,32 @@ protected: { const IntegerMatrix& sk = (*SK_list)[i]; (*ret)[i] = LogicalMatrix(sk.nrow(), sk.ncol()); + + Rcpp::rownames((*ret)[i]) = Rcpp::rownames(sk); + Rcpp::colnames((*ret)[i]) = Rcpp::colnames(sk); } - // TODO return *ret; } - void tryPerformMove(List& adjs, double* score, uint32_t listID, uint32_t from, uint32_t to, ChangeType action) + void tryPerformMove(List& adjs, NumericVector* score, uint32_t listID, uint32_t from, uint32_t to, ChangeType action) { + Rcout << "Trying to "; + if(action == ChangeType::ADD) + { + Rcout << "ADD"; + } + else{ + Rcout << "REMOVE"; + } + + Rcout << " edge: " << listID << ", " << from << ", " << to << "\n"; + + + + + NumericVector scoreChanges = (*this->input_data.score_change_func) ( adjs, @@ -377,26 +355,51 @@ protected: *this->input_data.bge_param, *this->input_data.sizes, *score, + listID, from, to, action == ChangeType::ADD); + + /* + * Here I test 3 approaches to find the difference, because: + * We are dealing with 1e-20 and more precision, thus + * straightforward computation may overflow/underflow + */ + double per_part_diff = (scoreChanges[0] - (*score)[0]) + (scoreChanges[1] - (*score)[1]); - double score_new = scoreChanges[0] * scoreChanges[1]; + double log_score_new = scoreChanges[0] + scoreChanges[1]; + double log_score_old = (*score)[0] + (*score)[1]; + double diff = log_score_new - log_score_old; - double normalize_c = *score + score_new; + double mod_diff = (scoreChanges[3] + scoreChanges[4]); + Rcout << mod_diff << "\n"; - NumericVector probs = {*score, score_new}; - probs = probs / normalize_c; + // Modified(explicit per-partes) is used + diff = exp(mod_diff); + + NumericVector probs = {1.0, diff}; + probs = probs / Rcpp::sum(probs); IntegerVector ids = {0, 1}; IntegerVector ret = Rcpp::sample(ids, 1, probs = probs); + if(ret[0] != 1) return; - *score = score_new; + *score = scoreChanges; this->makeMove(adjs, listID, from, to, action); + + if(action == ChangeType::ADD) + { + Rcout << "Adding"; + } + else{ + Rcout << "Removing"; + } + + Rcout << " edge: " << listID << ", " << from << ", " << to << "\n"; } @@ -407,6 +410,7 @@ protected: toAdd->to = to; toAdd->listID = listID; toAdd->type = action; + toAdd->is_graph = true; toAdd->prev = this->V_G.empty() ? nullptr : this->V_G[this->V_G.size() - 1]; toAdd->forward(adjs);